Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 18/20 | 0.45 |
| ▸ | MMP14 | P50281 | 9/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | MMP12 | P39900 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12377094 | 0.83 | GRM5 (0.61) | MMP13MMP14GRM5MMP12 | |
| SCHEMBL4008864 | 0.81 | MMP13 (0.39) | MMP13MMP14MMP12 | |
| SCHEMBL8148826 | 0.80 | MMP13 (0.37) | MMP13MMP14MMP12 | |
| SCHEMBL4009583 | 0.79 | MMP13 (0.44) | MMP13MMP14MMP12 | |
| SCHEMBL2292206 | 0.79 | MMP13 (0.44) | MMP13MMP14MMP12 | |
| SCHEMBL8138164 | 0.79 | MMP13 (0.40) | MMP13MMP14MMP12 | |
| SCHEMBL4009539 | 0.78 | MMP13 (0.38) | MMP13MMP14MMP12 | |
| SCHEMBL8125080 | 0.78 | MMP13 (0.38) | MMP13MMP14MMP12 | |
| SCHEMBL5241113 | 0.78 | MMP13 (0.43) | MMP13MMP14MMP12 | |
| SCHEMBL2289321 | 0.78 | MMP13 (0.43) | MMP13MMP14MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007747-A2 | HYDANTOIN DERIVATIVES USED AS MMP12 INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |