Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 2/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370472 | 0.83 | PDK2 (0.44) | HTR2ASLC6A4KCNH2PTPN7DUSP3 | |
| SCHEMBL4370075 | 0.80 | S1PR4 (0.57) | S1PR4NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1623536 | 0.78 | S1PR4 (0.55) | S1PR4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3933434 | 0.78 | AKT1 (0.35) | S1PR4HTR2ASLC6A4KCNH2PTPN7 | |
| SCHEMBL22809630 | 0.71 | SLC7A5 (0.48) | SMN1; SMN2PDK2 | |
| SCHEMBL586317 | 0.70 | PTPN7 (0.45) | HTR2ASLC6A4KCNH2PTPN7DUSP3 | |
| Hydrochloric Acid SCHEMBL30450550 | 0.70 | SLC7A5 (0.47) | SMN1; SMN2PDK2 | |
| Hydrochloric Acid SCHEMBL20595234 | 0.70 | SLC7A5 (0.47) | SMN1; SMN2PDK2 | |
| SCHEMBL2135911 | 0.69 | S1PR4 (0.47) | S1PR4PDE2A | |
| SCHEMBL6832255 | 0.69 | NQO1 (0.46) | HTR2ASLC6A4KCNH2PTPN7DUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044019-A1 | 3-OXOISOINDOLINE-1-CARBOXAMIDE DERIVATIVES AS ANALGESIC AGENTS | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008020-A1 | 3-OXOISOINDOLINE-1-CARBOXAMIDE DERIVATIVES AS ANALGESIC AGENTS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |