Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 6/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.31 |
| ▸ | GRM8 | O00222 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933432 | 0.78 | S1PR4 (0.46) | RXRAGRIN1GRIN2BS1PR4HTR2A | |
| SCHEMBL4370472 | 0.65 | PDK2 (0.44) | HTR2ASLC6A4KCNH2MPLPTPN7 | |
| SCHEMBL6832255 | 0.63 | NQO1 (0.46) | RXRAGRIN1GRIN2BHTR2ASLC6A4 | |
| SCHEMBL12896068 | 0.60 | SLC6A4 (0.43) | RXRAHTR2ASLC6A4KCNH2 | |
| SCHEMBL2135911 | 0.60 | S1PR4 (0.47) | CYP1A2CYP2C9S1PR4 | |
| SCHEMBL27732218 | 0.60 | HTR2A (0.40) | HTR2ASLC6A4KCNH2MPLPTPN7 | |
| SCHEMBL13074919 | 0.59 | HTR2A (0.42) | HTR2ASLC6A4KCNH2MPLPTPN7 | |
| SCHEMBL4370075 | 0.59 | S1PR4 (0.57) | CYP2C9S1PR4 | |
| SCHEMBL586317 | 0.58 | PTPN7 (0.45) | HTR2ASLC6A4KCNH2MPLPTPN7 | |
| SCHEMBL756255 | 0.58 | PTPN7 (0.50) | RXRAGRIN1GRIN2BHTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044019-A1 | 3-OXOISOINDOLINE-1-CARBOXAMIDE DERIVATIVES AS ANALGESIC AGENTS | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008020-A1 | 3-OXOISOINDOLINE-1-CARBOXAMIDE DERIVATIVES AS ANALGESIC AGENTS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |