Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14909587 | 0.90 | HRH3 (0.40) | HRH3SLC6A3SIGMAR1LTA4HACHE | |
| SCHEMBL3180816 | 0.87 | SIGMAR1 (0.44) | HRH3SIGMAR1HTR1DHTR1B | |
| SCHEMBL29974812 | 0.74 | ACHE (0.49) | MPODRD2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL16341499 | 0.74 | ACHE (0.49) | MPODRD2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL18940321 | 0.73 | ACHE (0.47) | MPODRD2SLC6A4SLC6A3HRH1 | |
| SCHEMBL6034728 | 0.73 | SIGMAR1 (0.46) | HRH4HRH3DRD2SLC6A4SLC6A3 | |
| SCHEMBL3937827 | 0.73 | TLR8 (0.40) | HRH4HRH3HRH1 | |
| SCHEMBL5188947 | 0.71 | ACHE (0.65) | HRH3MPODRD2SLC6A4SLC6A3 | |
| SCHEMBL28478478 | 0.70 | DPP7 (0.43) | HRH3SIGMAR1 | |
| SCHEMBL3184549 | 0.70 | HRH1 (0.36) | HRH4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |