Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL779513 | 0.88 | GPR119 (0.40) | POLBCHRNA7 | |
| SCHEMBL3941127 | 0.88 | KMT2A (0.38) | KMT2ADRD2DRD3CHRNA7 | |
| SCHEMBL779291 | 0.79 | CHRNA7 (0.52) | CHRNA7 | |
| Hydrochloric Acid SCHEMBL779238 | 0.78 | KCNH2 (0.53) | CHRNA7 | |
| SCHEMBL779305 | 0.74 | POLB (0.42) | POLBCHRNA7 | |
| SCHEMBL3934024 | 0.74 | CHRNA7 (0.54) | CHRNA7 | |
| SCHEMBL3933157 | 0.73 | CHRNA1 (0.40) | DRD2DRD3CHRNA7 | |
| SCHEMBL781380 | 0.73 | GBA1 (0.41) | — | |
| SCHEMBL10278549 | 0.72 | GPR119 (0.42) | CHRNA7 | |
| SCHEMBL3928181 | 0.72 | CHRNA7 (0.42) | KMT2ADRD2DRD3CHRNA7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044038-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | Cornerstone Therapeutics Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146066-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CRITICAL THERAPEUTICS, INC. (US) | 2007-12-21 | — | — | WO | disclosed |