Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLS | O94925 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL505937 | 0.81 | CTSK (0.48) | CTSKCTSSGABRB1GABRB2ALDH1A1 | |
| SCHEMBL320557 | 0.81 | CTSK (0.48) | CTSKCTSSGABRB1GABRB2ALDH1A1 | |
| SCHEMBL5263828 | 0.79 | SLC7A5 (0.38) | MAPTALDH1A1 | |
| SCHEMBL12203593 | 0.78 | CTSK (0.62) | CTSKCTSSMAPTATMGABRB1 | |
| SCHEMBL6346032 | 0.78 | CTSK (0.62) | CTSKCTSSMAPTATMGABRB1 | |
| SCHEMBL6346030 | 0.78 | CTSK (0.62) | CTSKCTSSMAPTATMGABRB1 | |
| SCHEMBL6487442 | 0.78 | CTSK (0.47) | CTSKCTSSGABRB1GABRB2GLS | |
| SCHEMBL2008100 | 0.78 | CTSK (0.47) | CTSKCTSSGABRB1GABRB2GLS | |
| SCHEMBL19479409 | 0.78 | CTSK (0.47) | CTSKCTSSATMGABRB1GABRB2 | |
| SCHEMBL781623 | 0.78 | CTSK (0.47) | CTSKCTSSGABRB1GABRB2GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041118-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | disclosed |