Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.63 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.61 |
| ▸ | CSF1R | P07333 | 3/20 | 0.58 |
| ▸ | KIT | P10721 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2498509 | 0.89 | BTK (0.66) | — | |
| SCHEMBL3487444 | 0.89 | CYP11B2 (0.72) | BRAFCYP11B2CSF1RNPC1NAMPT | |
| SCHEMBL2943457 | 0.85 | LCK (0.54) | BRAFKITKDRMAPK14ALDH1A1 | |
| SCHEMBL3930125 | 0.84 | CYP11B2 (0.68) | CYP11B2CSF1RALDH1A1CYP11B1KDM4E | |
| SCHEMBL13161982 | 0.84 | BRAF (0.74) | BRAFCYP11B2CSF1RKITKDR | |
| SCHEMBL3940427 | 0.84 | CYP11B2 (0.71) | CYP11B2CSF1RNAMPTALDH1A1HTT | |
| SCHEMBL3936760 | 0.83 | GAA (0.76) | NPC1POLBMAPTNAMPTALDH1A1 | |
| SCHEMBL21022088 | 0.83 | TYK2 (0.65) | NPC1POLBMAPTALDH1A1HTT | |
| SCHEMBL3943800 | 0.83 | BRAF (0.80) | BRAFCYP11B2CSF1RNAMPT | |
| SCHEMBL3941714 | 0.82 | BRAF (0.83) | BRAFCSF1RKITKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |
| WO-2006067445-A2 | CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |