Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.57 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934041 | 0.83 | BRAF (0.63) | MAPTNPC1KDM4EPOLBALDH1A1 | |
| SCHEMBL3934052 | 0.81 | GAA (0.69) | GAARAB9AMAPTNPC1KDM4E | |
| SCHEMBL13162558 | 0.81 | POLB (0.75) | GAARAB9AMAPTNPC1KDM4E | |
| SCHEMBL3487444 | 0.81 | CYP11B2 (0.72) | GAANPC1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3930125 | 0.81 | CYP11B2 (0.68) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL3940427 | 0.81 | CYP11B2 (0.71) | KDM4ELMNAALDH1A1TP53NAMPT | |
| SCHEMBL4034779 | 0.80 | GAA (0.53) | GAARAB9AMAPTNPC1KDM4E | |
| SCHEMBL2747860 | 0.80 | LMNA (0.79) | GAARAB9AMAPTNPC1KDM4E | |
| SCHEMBL21022130 | 0.80 | STAT3 (0.73) | RAB9AMAPTNPC1SMN1; SMN2POLB | |
| SCHEMBL12978039 | 0.79 | GAA (0.84) | GAARAB9AMAPTNPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |