Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.65 |
| ▸ | CSF1R | P07333 | 3/20 | 0.65 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934814 | 0.87 | BRAF (0.62) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3932944 | 0.81 | BRAF (0.82) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3933131 | 0.79 | BRAF (0.71) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3940458 | 0.79 | BRAF (0.63) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL1276318 | 0.79 | BRAF (1.00) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3937474 | 0.78 | BRAF (0.59) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3937075 | 0.78 | BRAF (0.85) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL3943800 | 0.77 | BRAF (0.80) | BRAFCSF1RNAMPT | |
| SCHEMBL1276797 | 0.77 | BRAF (0.78) | BRAFCSF1RKITMAPK14KDR | |
| SCHEMBL4014402 | 0.77 | BRAF (0.74) | BRAFCSF1RKITMAPK14KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |