Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.62 |
| ▸ | NAMPT | P43490 | 4/20 | 0.59 |
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934068 | 0.87 | BRAF (0.65) | BRAFNAMPTCSF1RKITKDR | |
| SCHEMBL3937474 | 0.86 | BRAF (0.59) | BRAFCSF1RCYP11B2KITKDR | |
| SCHEMBL3940458 | 0.86 | BRAF (0.63) | BRAFNAMPTCSF1RCYP11B2KIT | |
| SCHEMBL27720496 | 0.85 | BRAF (0.55) | BRAFNAMPTCSF1RCYP11B2KIT | |
| SCHEMBL3943800 | 0.81 | BRAF (0.80) | BRAFNAMPTCSF1RSMN1; SMN2CYP11B2 | |
| SCHEMBL3932898 | 0.80 | BRAF (0.59) | BRAFNAMPTCSF1RCYP11B2KIT | |
| SCHEMBL3937724 | 0.78 | CSF1R (0.83) | BRAFCSF1RCYP11B2KITKDR | |
| SCHEMBL3941714 | 0.78 | BRAF (0.83) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3935960 | 0.78 | BRAF (0.68) | BRAFCSF1RCYP11B2KITKDR | |
| SCHEMBL27720411 | 0.77 | CYP11B2 (0.76) | BRAFCSF1RCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |