Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 11/20 | 1.00 |
| ▸ | BRAF | P15056 | 4/20 | 0.77 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.59 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.59 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.59 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934404 | 0.91 | CSF1R (0.83) | CSF1RBRAFNPC1RAB9AL3MBTL1 | |
| SCHEMBL3931363 | 0.89 | CSF1R (0.80) | CSF1RBRAF | |
| SCHEMBL1276793 | 0.89 | CSF1R (1.00) | CSF1RBRAF | |
| SCHEMBL3934893 | 0.88 | CSF1R (0.85) | CSF1RBRAFL3MBTL1 | |
| SCHEMBL23565666 | 0.87 | BRAF (0.76) | CSF1RBRAFKCNQ3KCNQ2KCNE1 | |
| SCHEMBL3930070 | 0.87 | CSF1R (1.00) | CSF1RBRAFNPC1RAB9A | |
| SCHEMBL3942520 | 0.87 | BRAF (1.00) | CSF1RBRAF | |
| SCHEMBL3937374 | 0.87 | CSF1R (0.80) | CSF1RBRAFNPC1RAB9A | |
| SCHEMBL3941840 | 0.87 | CSF1R (1.00) | CSF1RBRAFNPC1 | |
| SCHEMBL3936075 | 0.86 | CSF1R (1.00) | CSF1RBRAFNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |