Sugi Predict

Sugi Predict / Compounds / SCHEMBL3931363

SCHEMBL3931363

SCHEMBL3931363

O=C(Nc1ccc(F)c(C(=O)Nc2cccnc2)c1)c1cccc(F)c1

nearest known ligand 0.80

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 8/20 0.80
▸ BRAF P15056 6/20 0.80
▸ CYP11B1 P15538 3/20 0.64
▸ CYP11B2 P19099 3/20 0.64
▸ TAAR1 Q96RJ0 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3931994 0.91 CSF1R (0.65) CSF1RBRAFCYP11B1CYP11B2
SCHEMBL3936478 0.90 CSF1R (0.81) CSF1RBRAFCYP11B1CYP11B2
SCHEMBL23565666 0.89 BRAF (0.76) CSF1RBRAFCYP11B1CYP11B2TAAR1
SCHEMBL3942520 0.89 BRAF (1.00) CSF1RBRAF
SCHEMBL3935559 0.89 BRAF (0.80) CSF1RBRAFCYP11B1CYP11B2
SCHEMBL3934183 0.89 CSF1R (1.00) CSF1RBRAF
SCHEMBL3941905 0.89 CSF1R (0.77) CSF1RBRAFCYP11B1CYP11B2
SCHEMBL4020844 0.89 CSF1R (0.64) CSF1RBRAFCYP11B1CYP11B2
SCHEMBL3937125 0.87 CSF1R (0.79) CSF1RBRAFCYP11B1CYP11B2
SCHEMBL3931681 0.86 BRAF (0.79) CSF1RBRAFCYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1831198-B1 PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS ASTRAZENECA AB (SE) 2009-04-08 — — EP disclosed
CN-101128454-A Pyridine carboxamide derivatives for use as anticancer agents ASTRAZENECA AB (SE) 2008-02-20 — — CN disclosed