Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 11/20 | 1.00 |
| ▸ | BRAF | P15056 | 6/20 | 0.80 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.64 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932812 | 0.91 | CSF1R (1.00) | CSF1RBRAFNPC1 | |
| SCHEMBL3937779 | 0.89 | BRAF (1.00) | CSF1RBRAFKCNK3KCNK9 | |
| SCHEMBL1276793 | 0.89 | CSF1R (1.00) | CSF1RBRAF | |
| SCHEMBL31661935 | 0.87 | BRAF (0.79) | CSF1RBRAFKCNK3KCNK9NPC1 | |
| SCHEMBL12979 | 0.87 | BRAF (0.79) | CSF1RBRAFKCNK3KCNK9NPC1 | |
| SCHEMBL3942712 | 0.87 | CSF1R (1.00) | CSF1RBRAFNPC1 | |
| SCHEMBL3930070 | 0.87 | CSF1R (1.00) | CSF1RBRAFNPC1 | |
| SCHEMBL3937374 | 0.87 | CSF1R (0.80) | CSF1RBRAFNPC1 | |
| SCHEMBL3934183 | 0.87 | CSF1R (1.00) | CSF1RBRAFNPC1 | |
| SCHEMBL3935559 | 0.87 | BRAF (0.80) | CSF1RBRAFKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |