Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCL9 | O00512 | 6/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 6/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3935721 | 0.93 | PTGDR2 (0.51) | PTGDR2BCL9CTNNB1HSD11B1AKR1C3 | |
| SCHEMBL3936240 | 0.89 | TSHR (0.46) | TSHRLMNAKDM4EALDH1A1GAA | |
| SCHEMBL3933836 | 0.87 | PTGDR2 (0.51) | TSHRPTGDR2BCL9CTNNB1HSD11B1 | |
| SCHEMBL3942412 | 0.86 | PTGDR2 (0.51) | TSHRALDH1A1PKMPTGDR2KMT2A | |
| SCHEMBL3936225 | 0.85 | BCL9 (0.48) | LMNAALDH1A1GAAMAPTKMT2A | |
| SCHEMBL3928445 | 0.84 | BCL9 (0.47) | TSHRLMNAALDH1A1PTGDR2KMT2A | |
| SCHEMBL3932402 | 0.84 | CNR1 (0.52) | PTGDR2KMT2ABCL9CTNNB1 | |
| SCHEMBL3940869 | 0.84 | CNR1 (0.49) | PTGDR2KMT2ABCL9CTNNB1AKR1C3 | |
| SCHEMBL4110985 | 0.84 | SMN1; SMN2 (0.48) | LMNAGAAMAPTPTGDR2KMT2A | |
| SCHEMBL3941700 | 0.83 | BCL9 (0.54) | LMNAALDH1A1GAAPTGDR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | claimed |
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |