Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 6/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3935774 | 0.94 | ATM (0.46) | TSHRHSD11B1ATMBCL9CTNNB1 | |
| SCHEMBL3934277 | 0.89 | TSHR (0.49) | TSHRHSD11B1ATMBCL9CTNNB1 | |
| SCHEMBL3936109 | 0.88 | ATM (0.47) | TSHRATMBCL9CTNNB1MAPT | |
| SCHEMBL3935500 | 0.87 | BCL9 (0.46) | ATMBCL9CTNNB1LMNAKMT2A | |
| SCHEMBL3936324 | 0.87 | EPHX2 (0.45) | TSHRATMBCL9CTNNB1LMNA | |
| SCHEMBL3932848 | 0.85 | BCL9 (0.47) | ATMBCL9CTNNB1LMNAALDH1A1 | |
| SCHEMBL3930615 | 0.85 | CNR1 (0.47) | TSHRBCL9CTNNB1KMT2AALDH1A1 | |
| SCHEMBL3941279 | 0.85 | BCL9 (0.46) | TSHRATMBCL9CTNNB1KMT2A | |
| SCHEMBL3941513 | 0.85 | SMN1; SMN2 (0.48) | BCL9CTNNB1LMNAKMT2AMAPT | |
| SCHEMBL3942001 | 0.84 | MAPT (0.49) | TSHRATMBCL9CTNNB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |