Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 12/20 | 0.48 |
| ▸ | KDM6B | O15054 | 5/20 | 0.48 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379950 | 0.89 | POLB (0.54) | KDM4CKDM6BKDM4DTDP1ALDH1A1 | |
| SCHEMBL29369561 | 0.89 | POLB (0.54) | KDM4CKDM6BKDM4DTDP1ALDH1A1 | |
| SCHEMBL29460073 | 0.87 | POLB (0.52) | KDM4CKDM6BKDM4DTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3827644 | 0.87 | POLB (0.52) | KDM4CKDM6BKDM4DTDP1ALDH1A1 | |
| SCHEMBL28242959 | 0.85 | KDM4C (0.46) | KDM4CKDM6BKDM4DTDP1ALDH1A1 | |
| SCHEMBL9017980 | 0.85 | TDP1 (0.53) | KDM4CKDM6BKDM4DTDP1ALDH1A1 | |
| SCHEMBL30802769 | 0.81 | KDM4C (0.48) | KDM4CKDM6BKDM4DTDP1ALDH1A1 | |
| SCHEMBL1244826 | 0.81 | KDM4C (0.49) | KDM4CKDM6BKDM4DTDP1ALDH1A1 | |
| SCHEMBL30017034 | 0.77 | KDM4C (0.53) | KDM4CKDM6BKDM4DTDP1ALDH1A1 | |
| SCHEMBL115907 | 0.77 | KDM4C (0.53) | KDM4CKDM6BKDM4DTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044050-A1 | NEW PYRIDINE ANALOGUES | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008004946-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |