Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | CSF1R | P07333 | 11/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | BRAF | P15056 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932583 | 0.92 | CSF1R (0.79) | LMNACSF1RGAABRAF | |
| SCHEMBL3937480 | 0.88 | GAA (0.79) | LMNACSF1RGAABRAF | |
| SCHEMBL27699790 | 0.88 | LMNA (0.79) | LMNACSF1RGAAALDH1A1BRAF | |
| SCHEMBL12978269 | 0.88 | LMNA (1.00) | LMNAGAAALDH1A1 | |
| SCHEMBL3938624 | 0.87 | CSF1R (0.81) | CSF1RGAAALDH1A1BRAF | |
| SCHEMBL3936075 | 0.86 | CSF1R (1.00) | CSF1RBRAF | |
| SCHEMBL3936904 | 0.85 | CSF1R (1.00) | CSF1RALDH1A1BRAF | |
| SCHEMBL3938361 | 0.85 | CSF1R (0.84) | CSF1RGAAALDH1A1BRAF | |
| SCHEMBL3942712 | 0.84 | CSF1R (1.00) | CSF1RBRAF | |
| SCHEMBL3941843 | 0.82 | BRAF (0.77) | LMNACSF1RGAABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |