Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 1.00 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 1.00 |
| ▸ | MELK | Q14680 | 1/20 | 1.00 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 1.00 |
| ▸ | PARP1 | P09874 | 6/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.52 |
| ▸ | TYMS | P04818 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3117561 | 0.76 | JAK2 (0.61) | JAK2RPS6KA3MELKSTK24PARP1 | |
| SCHEMBL6798992 | 0.76 | JAK2 (0.61) | JAK2RPS6KA3MELKSTK24PARP1 | |
| SCHEMBL168637 | 0.76 | JAK2 (0.61) | JAK2RPS6KA3MELKSTK24PARP1 | |
| SCHEMBL11775264 | 0.76 | JAK2 (0.61) | JAK2RPS6KA3MELKSTK24PARP1 | |
| SCHEMBL6306041 | 0.74 | JAK2 (0.59) | JAK2RPS6KA3MELKSTK24PARP1 | |
| SCHEMBL34467598 | 0.74 | PDPK1 (0.62) | JAK2RPS6KA3MELKSTK24PARP1 | |
| SCHEMBL24367974 | 0.73 | JAK2 (0.58) | JAK2RPS6KA3MELKSTK24PARP1 | |
| SCHEMBL23972210 | 0.73 | JAK2 (0.58) | JAK2RPS6KA3MELKSTK24PARP1 | |
| SCHEMBL65699 | 0.72 | JAK2 (0.54) | JAK2RPS6KA3MELKSTK24RECQL | |
| SCHEMBL29349435 | 0.72 | JAK2 (0.54) | JAK2RPS6KA3MELKSTK24RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009404-A4 | METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS | OCTAMER INC (US) | 2009-07-01 | — | — | EP | claimed |
| EP-1009404-A1 | METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS | Octamer, Inc. (US) | 2000-06-21 | — | — | EP | claimed |
| US-5908861-A | Methods for treating inflammation and inflammatory disease using pADPRT inhibitors | OCTAMER, INC. (US) | 1999-06-01 | — | — | US | claimed |
| WO-1998051308-A1 | METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS | OCTAMER, INC. (US) | 1998-11-19 | — | — | WO | claimed |
| WO-1998051307-A1 | METHODS FOR TREATING INFLAMMATION, INFLAMMATORY DISEASES, ARTHRITIS AND STROKE USING pADPRT INHIBITORS | OCTAMER, INC. (US) | 1998-11-19 | — | — | WO | claimed |
| US-20230348456-A1 | QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME | REPARE THERAPEUTICS INC. (CA) | 2023-11-02 | — | — | US | disclosed |
| US-20230348456-A1 | QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME | REPARE THERAPEUTICS INC. (CA) | 2023-11-02 | — | — | US | disclosed |
| US-20230348456-A1 | QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME | REPARE THERAPEUTICS INC. (CA) | 2023-11-02 | — | — | US | disclosed |
| EP-1009404-A4 | METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS | OCTAMER INC (US) | 2009-07-01 | — | — | EP | disclosed |
| US-6303629-B1 | TREATING ARTHRITIS IN AN ANIMAL OR MAMMAL BY ADMINISTERING TO AN ANIMAL OR MAMMAL A INHIBITOR OF NUCLEAR ENZYME POLY-ADP RIBOSE POLYMERASE (PADPRT) | OCTAMER, INC. | 2001-10-16 | — | — | US | disclosed |
| EP-1009404-A1 | METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS | Octamer, Inc. (US) | 2000-06-21 | — | — | EP | disclosed |
| US-5908861-A | Methods for treating inflammation and inflammatory disease using pADPRT inhibitors | OCTAMER, INC. (US) | 1999-06-01 | — | — | US | disclosed |
| WO-1998051308-A1 | METHODS FOR TREATING INFLAMMATION AND INFLAMMATORY DISEASES USING pADPRT INHIBITORS | OCTAMER, INC. (US) | 1998-11-19 | — | — | WO | disclosed |
| WO-1998051307-A1 | METHODS FOR TREATING INFLAMMATION, INFLAMMATORY DISEASES, ARTHRITIS AND STROKE USING pADPRT INHIBITORS | OCTAMER, INC. (US) | 1998-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348456-A1 | QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME | CSNK1A1, CSNK1G1, CSNK1G3 | JAK2 274/4885RPS6KA3 376/4885MELK 626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.