Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 10/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.59 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941536 | 0.89 | BRAF (0.79) | CSF1RNPC1RAB9ATSHRBRAF | |
| SCHEMBL3938624 | 0.89 | CSF1R (0.81) | CSF1RRAB9ABRAFALDH1A1PKM | |
| SCHEMBL3936075 | 0.82 | CSF1R (1.00) | CSF1RNPC1RAB9ABRAF | |
| SCHEMBL3932029 | 0.82 | MAPK1 (0.79) | CSF1RNPC1RAB9ATSHRBRAF | |
| SCHEMBL3938361 | 0.82 | CSF1R (0.84) | CSF1RRAB9ATSHRBRAFALDH1A1 | |
| SCHEMBL3942712 | 0.81 | CSF1R (1.00) | CSF1RNPC1BRAF | |
| SCHEMBL3934338 | 0.81 | NPC1 (0.78) | CSF1RNPC1RAB9ATSHRBRAF | |
| SCHEMBL3932812 | 0.81 | CSF1R (1.00) | CSF1RNPC1BRAF | |
| SCHEMBL3936904 | 0.80 | CSF1R (1.00) | CSF1RRAB9ATSHRBRAFALDH1A1 | |
| SCHEMBL3944209 | 0.80 | CSF1R (0.74) | CSF1RNPC1RAB9ABRAFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |