Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 11/20 | 0.74 |
| ▸ | BRAF | P15056 | 3/20 | 0.69 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.67 |
| ▸ | TYK2 | P29597 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3937459 | 0.90 | BRAF (0.84) | CSF1RBRAFCYP11B2POLBKMT2A | |
| SCHEMBL13162010 | 0.90 | BRAF (0.71) | CSF1RBRAFCYP11B2POLBKMT2A | |
| SCHEMBL3938624 | 0.89 | CSF1R (0.81) | CSF1RBRAFPOLBKMT2ARAB9A | |
| SCHEMBL3936904 | 0.85 | CSF1R (1.00) | CSF1RBRAFKMT2ARAB9AALDH1A1 | |
| SCHEMBL3938361 | 0.85 | CSF1R (0.84) | CSF1RBRAFPOLBKMT2ARAB9A | |
| SCHEMBL3932583 | 0.84 | CSF1R (0.79) | CSF1RBRAFCYP11B2NPC1 | |
| SCHEMBL3942712 | 0.82 | CSF1R (1.00) | CSF1RBRAFCYP11B2NPC1 | |
| SCHEMBL3936918 | 0.82 | BRAF (1.00) | CSF1RBRAFPOLBKMT2ARAB9A | |
| SCHEMBL3934629 | 0.81 | LMNA (0.77) | CSF1RBRAFALDH1A1 | |
| SCHEMBL13162340 | 0.81 | BRAF (0.79) | CSF1RBRAFCYP11B2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |