Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | CSF1R | P07333 | 11/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | BRAF | P15056 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4165366 | 0.90 | MAPK1 (0.81) | MAPK1TSHRCSF1RBRAFNPC1 | |
| SCHEMBL3941916 | 0.89 | MAPK1 (0.79) | MAPK1TSHRCSF1RMAPTBRAF | |
| SCHEMBL3934096 | 0.88 | BRAF (0.81) | MAPK1TSHRCSF1RMAPTBRAF | |
| SCHEMBL3936904 | 0.87 | CSF1R (1.00) | TSHRCSF1RBRAFRAB9AALDH1A1 | |
| SCHEMBL3936515 | 0.86 | CSF1R (0.83) | CSF1RBRAFNPC1RAB9AALDH1A1 | |
| SCHEMBL3934792 | 0.82 | CSF1R (0.70) | TSHRCSF1RMAPTBRAFNPC1 | |
| SCHEMBL3941840 | 0.82 | CSF1R (1.00) | CSF1RBRAFNPC1 | |
| SCHEMBL3930070 | 0.82 | CSF1R (1.00) | CSF1RMAPTBRAFNPC1RAB9A | |
| SCHEMBL1276793 | 0.82 | CSF1R (1.00) | CSF1RBRAFMEN1KMT2A | |
| SCHEMBL3938361 | 0.81 | CSF1R (0.84) | TSHRCSF1RBRAFRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |