Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14430941 | 0.79 | ALDH1A1 (0.39) | ALDH1A1MAPK1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL10351871 | 0.77 | ALDH1A1 (0.37) | ALDH1A1MAPK1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL776173 | 0.77 | ALDH1A1 (0.37) | ALDH1A1MAPK1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL2945120 | 0.77 | CYP1A2 (0.53) | ALDH1A1MAPK1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL2950715 | 0.77 | ALDH1A1 (0.37) | ALDH1A1MAPK1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL1454164 | 0.76 | ALDH1A1 (0.36) | ALDH1A1MAPK1HPGDMAPTSMN1; SMN2 | |
| Barium SCHEMBL2729092 | 0.76 | ALDH1A1 (0.36) | ALDH1A1MAPK1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL285276 | 0.74 | ALDH1A1 (0.34) | ALDH1A1MAPK1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL19622359 | 0.73 | MAPT (0.41) | ALDH1A1MAPK1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL1454773 | 0.72 | KIF11 (0.36) | ALDH1A1MAPK1HPGDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043644-A1 | NF- B INHIBITOR | Otsuka Pharmaceutical Co., Ltd. (JP) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008010601-A1 | NF- ϰB INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-01-24 | — | — | WO | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |