Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 8/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9672399 | 0.84 | CA1 (0.53) | ALDH1A1TSHRMAPTNPC1HTT | |
| SCHEMBL3458276 | 0.80 | PTPN11 (0.51) | ALDH1A1TSHRMAPTPTPN11RAB9A | |
| SCHEMBL110051 | 0.79 | ALDH1A1 (0.64) | ADRB2ADRB1ADRB3PLA2G1BATG4B | |
| SCHEMBL27668055 | 0.78 | ALDH1A1 (0.62) | ADRB2ADRB1ADRB3PLA2G1BATG4B | |
| SCHEMBL27668352 | 0.78 | ALDH1A1 (0.62) | ADRB2ADRB1ADRB3PLA2G1BATG4B | |
| SCHEMBL27667934 | 0.78 | ALDH1A1 (0.62) | ADRB2ADRB1ADRB3PLA2G1BATG4B | |
| SCHEMBL1561253 | 0.77 | GABRA1 (0.47) | ALDH1A1PTPN2PTPN1PTPN6PTPN11 | |
| SCHEMBL2896389 | 0.75 | ACACB (0.45) | ALDH1A1MAPTRAB9A | |
| SCHEMBL27929357 | 0.73 | KMT2A (0.60) | ADRB2ADRB1ADRB3PLA2G1BATG4B | |
| SCHEMBL5167985 | 0.73 | CA12 (0.63) | ADRB2ADRB1ADRB3PLA2G1BATG4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046787-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | Glaxo Group Limited (GB) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008015416-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-02-07 | — | — | WO | disclosed |