Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 16/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29978735 | 0.84 | TDP1 (0.61) | KDM4ETDP1ALDH1A1KMT2ATRPV1 | |
| SCHEMBL4197626 | 0.84 | TDP1 (0.61) | KDM4ETDP1ALDH1A1KMT2ATRPV1 | |
| Hydrochloric Acid SCHEMBL6201867 | 0.83 | KDM4E (0.59) | KDM4ETDP1ALDH1A1KMT2ATRPV1 | |
| SCHEMBL14564497 | 0.82 | KDM4E (0.67) | KDM4ETDP1ALDH1A1KMT2ATRPV1 | |
| SCHEMBL912675 | 0.81 | KDM4E (0.77) | KDM4ETDP1ALDH1A1KMT2A | |
| SCHEMBL31586013 | 0.81 | KDM4E (0.77) | KDM4ETDP1ALDH1A1KMT2A | |
| SCHEMBL2557875 | 0.79 | KDM4E (0.62) | KDM4ETDP1ALDH1A1TRPV1 | |
| SCHEMBL4157627 | 0.79 | POLB (0.56) | KDM4ETDP1ALDH1A1KMT2ATRPV1 | |
| SCHEMBL31676801 | 0.79 | KDM4E (0.67) | KDM4ETDP1ALDH1A1KMT2ATRPV1 | |
| SCHEMBL3712467 | 0.79 | KDM4E (0.67) | KDM4ETDP1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014674-A1 | HETEROCYCLYLAMIDES AS GUT MICROSOMAL TRIGLYCERIDE TRANSPORT PROTEIN INHIBITORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009014674-A1 | HETEROCYCLYLAMIDES AS GUT MICROSOMAL TRIGLYCERIDE TRANSPORT PROTEIN INHIBITORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |