Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19654924 | 0.87 | POLB (0.68) | POLBL3MBTL1TSHRRAB9ACASP3 | |
| SCHEMBL20025053 | 0.80 | POLB (0.64) | POLBL3MBTL1TSHRRAB9ACASP3 | |
| SCHEMBL4741015 | 0.80 | ALDH1A1 (0.49) | POLBL3MBTL1TSHRRAB9ACASP3 | |
| SCHEMBL3935826 | 0.79 | KDM4E (0.61) | ALDH1A1KMT2AKDM4ETDP1TRPV1 | |
| SCHEMBL20192067 | 0.77 | POLB (0.64) | POLBL3MBTL1TSHRRAB9ACASP3 | |
| SCHEMBL2564440 | 0.75 | ALDH1A1 (0.60) | L3MBTL1TSHRRAB9AALDH1A1KMT2A | |
| SCHEMBL6266108 | 0.75 | POLB (0.69) | POLBL3MBTL1TSHRRAB9ACASP3 | |
| SCHEMBL18320469 | 0.75 | KMT2A (0.69) | L3MBTL1RAB9AALDH1A1KMT2ATDP1 | |
| SCHEMBL2858512 | 0.74 | TRPV1 (0.51) | L3MBTL1TSHRRAB9AALDH1A1KMT2A | |
| SCHEMBL20192070 | 0.74 | L3MBTL1 (0.59) | POLBL3MBTL1TSHRRAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014674-A1 | HETEROCYCLYLAMIDES AS GUT MICROSOMAL TRIGLYCERIDE TRANSPORT PROTEIN INHIBITORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
| WO-2009014674-A1 | HETEROCYCLYLAMIDES AS GUT MICROSOMAL TRIGLYCERIDE TRANSPORT PROTEIN INHIBITORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |