Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL6343864 | 0.98 | PDE4A (0.46) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL5471738 | 0.96 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL27429235 | 0.96 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL27660422 | 0.96 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL30410784 | 0.96 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Galactose SCHEMBL10596615 | 0.96 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Galactose SCHEMBL9726398 | 0.96 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL18886543 | 0.95 | PDE4A (0.48) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL20603115 | 0.95 | PDE4A (0.48) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL27552648 | 0.95 | PDE4A (0.48) | PDE4AUSP2SLCO1B1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041264-A2 | PRODUCTION OF D-LACTIC ACID WITH YEAST | Tate & Lyle Ingredients Americas, Inc. (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007149894-A2 | PRODUCTION OF D-LACTIC ACID WITH YEAST | TATE & LYLE INGREDIENTS AMERICAS, INC. (US) | 2007-12-27 | — | — | WO | disclosed |
| EP-1274856-A4 | FUNGAL LACTATE DEHYDROGENASE GENE AND CONSTRUCTS FOR THE EXPRESSION THEREOF | US AGRICULTURE (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1274856-A1 | FUNGAL LACTATE DEHYDROGENASE GENE AND CONSTRUCTS FOR THE EXPRESSION THEREOF | The United States of America, as represented by The Secretary of Agriculture (US) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001073098-A1 | FUNGAL LACTATE DEHYDROGENASE GENE AND CONSTRUCTS FOR THE EXPRESSION THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) | 2001-10-04 | — | — | WO | disclosed |