Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Galactose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Galactose SCHEMBL10596615 | 1.00 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL30410784 | 1.00 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL5471738 | 1.00 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL27429235 | 1.00 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL27660422 | 1.00 | PDE4A (0.50) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL20603115 | 0.98 | PDE4A (0.48) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL27552648 | 0.98 | PDE4A (0.48) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL18886543 | 0.98 | PDE4A (0.48) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL3935927 | 0.96 | PDE4A (0.47) | PDE4AUSP2SLCO1B1LMNATP53 | |
| Demannose SCHEMBL6343864 | 0.95 | PDE4A (0.46) | PDE4AUSP2SLCO1B1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5089398-A | Insertion Dna sequences | CHIRON CORPORATION (US) | 1992-02-18 | — | — | US | disclosed |