⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17329382 | 0.70 | — | — | |
| SCHEMBL25222941 | 0.67 | MAP3K14 (0.32) | — | |
| SCHEMBL24075136 | 0.63 | — | — | |
| SCHEMBL25203490 | 0.63 | P2RX7 (0.42) | — | |
| SCHEMBL25224764 | 0.63 | — | — | |
| SCHEMBL24075837 | 0.63 | P2RX7 (0.42) | — | |
| SCHEMBL24075728 | 0.63 | P2RX7 (0.42) | — | |
| SCHEMBL17961250 | 0.54 | ITGB2 (0.42) | — | |
| SCHEMBL39954 | 0.54 | — | — | |
| SCHEMBL16053482 | 0.52 | ITGB2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980938-B2 | CXCR2 inhibitors | SANOFI (FR) | 2015-03-17 | — | — | US | disclosed |
| US-8501981-B2 | CXCR2 inhibitors | SANOFI (FR) | 2013-08-06 | — | — | US | disclosed |
| US-20090258936-A1 | CXCR2 INHIBITORS | SANOFI-AVENTIS (FR) | 2009-10-15 | — | — | US | disclosed |
| US-20090227625-A1 | CXCR2 INHIBITORS | SANOFI-AVENTIS (FR) | 2009-09-10 | — | — | US | disclosed |
| EP-2041073-A1 | CXCR2 INHIBITORS | Sanofi-Aventis (FR) | 2009-04-01 | — | — | EP | disclosed |
| EP-2040688-A1 | NEW CXCR2 INHIBITORS | Sanofi-Aventis (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008000410-A1 | CXCR2 INHIBITORS | SANOFI-AVENTIS (FR) | 2008-01-03 | — | — | WO | disclosed |
| WO-2008000409-A1 | NEW CXCR2 INHIBITORS | SANOFI-AVENTIS (FR) | 2008-01-03 | — | — | WO | disclosed |