Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | GABRP | O00591 | 2/20 | 0.46 |
| ▸ | GABRD | O14764 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.46 |
| ▸ | GABRE | P78334 | 2/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16616066 | 0.82 | KEAP1 (0.55) | KEAP1NFE2L2GABRPGABRDGABRA1 | |
| SCHEMBL31344260 | 0.81 | KEAP1 (0.53) | KEAP1NFE2L2GABRPGABRDGABRA1 | |
| SCHEMBL9703855 | 0.81 | KEAP1 (0.53) | KEAP1NFE2L2GABRPGABRDGABRA1 | |
| SCHEMBL10564551 | 0.81 | KEAP1 (0.53) | KEAP1NFE2L2GABRPGABRDGABRA1 | |
| SCHEMBL2807041 | 0.79 | GABRP (0.47) | KEAP1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL23856563 | 0.78 | KEAP1 (0.70) | KEAP1NFE2L2GABRPGABRDGABRA1 | |
| SCHEMBL1505510 | 0.78 | KEAP1 (0.50) | KEAP1NFE2L2GABRPGABRDGABRA1 | |
| SCHEMBL3450933 | 0.78 | KEAP1 (0.50) | KEAP1NFE2L2GABRPGABRDGABRA1 | |
| SCHEMBL1330488 | 0.75 | KEAP1 (0.60) | KEAP1NFE2L2GABRPGABRDGABRA1 | |
| SCHEMBL11493973 | 0.74 | KDM4E (0.51) | KEAP1NFE2L2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054428-A1 | NOVEL PYRIMIDINE DERIVATIVES 965 | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
| WO-2009010794-A1 | 2,4-DIAMINO-PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054428-A1 | NOVEL PYRIMIDINE DERIVATIVES 965 | EPHB4, EPHB1, EPHB3 | KEAP1 1255/4885NFE2L2 2557/4885GABRP 4599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.