Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 9/20 | 0.81 |
| ▸ | BRAF | P15056 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.65 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1276793 | 0.90 | CSF1R (1.00) | CSF1RBRAFMEN1KMT2A | |
| SCHEMBL3931363 | 0.90 | CSF1R (0.80) | CSF1RBRAFCYP11B2CYP11B1 | |
| SCHEMBL1276903 | 0.88 | BRAF (1.00) | CSF1RBRAFMEN1KMT2ACYP11B2 | |
| SCHEMBL3935559 | 0.88 | BRAF (0.80) | CSF1RBRAFCYP11B2CYP11B1 | |
| SCHEMBL4020844 | 0.88 | CSF1R (0.64) | CSF1RBRAFCYP11B2CYP11B1 | |
| SCHEMBL3941905 | 0.88 | CSF1R (0.77) | CSF1RBRAFMEN1KMT2ACYP11B2 | |
| SCHEMBL3937125 | 0.86 | CSF1R (0.79) | CSF1RBRAFMEN1KMT2ACYP11B2 | |
| SCHEMBL3933275 | 0.85 | CSF1R (0.72) | CSF1RBRAFMEN1KMT2ACYP11B2 | |
| SCHEMBL3931681 | 0.85 | BRAF (0.79) | CSF1RBRAFCYP11B2CYP11B1 | |
| SCHEMBL3944890 | 0.85 | CSF1R (0.78) | CSF1RBRAFKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |