Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.80 |
| ▸ | CSF1R | P07333 | 6/20 | 0.77 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.61 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.58 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934268 | 0.91 | CSF1R (0.76) | BRAFCSF1RCYP11B1CYP11B2 | |
| SCHEMBL3937779 | 0.89 | BRAF (1.00) | BRAFCSF1RKCNK3KCNK9 | |
| SCHEMBL3931363 | 0.89 | CSF1R (0.80) | BRAFCSF1RCYP11B1CYP11B2 | |
| SCHEMBL3936478 | 0.88 | CSF1R (0.81) | BRAFCSF1RCYP11B1CYP11B2 | |
| SCHEMBL12979 | 0.87 | BRAF (0.79) | BRAFCSF1RKCNK3KCNK9 | |
| SCHEMBL31661935 | 0.87 | BRAF (0.79) | BRAFCSF1RKCNK3KCNK9 | |
| SCHEMBL3941905 | 0.87 | CSF1R (0.77) | BRAFCSF1RCYP11B1CYP11B2 | |
| SCHEMBL4020844 | 0.87 | CSF1R (0.64) | BRAFCSF1RCYP11B1CYP11B2 | |
| SCHEMBL3941840 | 0.87 | CSF1R (1.00) | BRAFCSF1RKCNK3KCNK9 | |
| SCHEMBL3931681 | 0.86 | BRAF (0.79) | BRAFCSF1RCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |