Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925705 | 0.91 | PTGDR2 (0.50) | ALDH1A1KDM4ESTAT3TP53SMN1; SMN2 | |
| SCHEMBL3934199 | 0.89 | KDM4E (0.54) | ALDH1A1KDM4ESTAT3TP53SMN1; SMN2 | |
| SCHEMBL3937412 | 0.88 | ALDH1A1 (0.62) | ALDH1A1KDM4ESTAT3TP53SMN1; SMN2 | |
| SCHEMBL3936875 | 0.87 | PTGDR2 (0.48) | ALDH1A1KDM4ESTAT3TP53SMN1; SMN2 | |
| SCHEMBL3928218 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KDM4ESTAT3TP53SMN1; SMN2 | |
| SCHEMBL3927288 | 0.86 | ALDH1A1 (0.51) | ALDH1A1KDM4ESTAT3TP53SMN1; SMN2 | |
| SCHEMBL3929988 | 0.85 | KDM4E (0.50) | ALDH1A1KDM4ESTAT3TP53SMN1; SMN2 | |
| SCHEMBL3937733 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KDM4ESTAT3TP53SMN1; SMN2 | |
| SCHEMBL3939227 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KDM4ESTAT3TP53SMN1; SMN2 | |
| SCHEMBL3938472 | 0.83 | ALDH1A1 (0.48) | ALDH1A1KDM4ESTAT3SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |