Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934199 | 0.96 | KDM4E (0.54) | ALDH1A1KDM4ESTAT3TP53PKM | |
| SCHEMBL3928709 | 0.92 | TP53 (0.55) | ALDH1A1KDM4ESTAT3TP53PKM | |
| SCHEMBL3928218 | 0.92 | ALDH1A1 (0.51) | ALDH1A1KDM4ESTAT3TP53PKM | |
| SCHEMBL3937412 | 0.89 | ALDH1A1 (0.62) | ALDH1A1KDM4ESTAT3TP53PKM | |
| SCHEMBL3938472 | 0.89 | ALDH1A1 (0.48) | ALDH1A1KDM4ESTAT3LMNASMN1; SMN2 | |
| SCHEMBL3933440 | 0.89 | PTGDR2 (0.54) | ALDH1A1KDM4ESTAT3POLBLMNA | |
| SCHEMBL3939227 | 0.89 | ALDH1A1 (0.49) | ALDH1A1KDM4ESTAT3TP53SMN1; SMN2 | |
| SCHEMBL4014322 | 0.88 | PTGDR2 (0.55) | ALDH1A1POLBLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL3931978 | 0.86 | MEN1 (0.54) | ALDH1A1KDM4ESTAT3TP53PKM | |
| SCHEMBL3936631 | 0.85 | ALDH1A1 (0.51) | ALDH1A1KDM4ESTAT3TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |