Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.57 |
| ▸ | MMP13 | P45452 | 14/20 | 0.55 |
| ▸ | MMP1 | P03956 | 13/20 | 0.55 |
| ▸ | MMP9 | P14780 | 10/20 | 0.55 |
| ▸ | MMP14 | P50281 | 2/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947785 | 0.98 | ADAM17 (0.57) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL3944455 | 0.98 | ADAM17 (0.57) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL3944450 | 0.98 | ADAM17 (0.57) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL7879785 | 0.89 | ADAM17 (0.52) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL7872276 | 0.87 | ADAM17 (0.53) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL6693978 | 0.84 | ADAM17 (0.55) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL4148426 | 0.80 | ADAM17 (0.59) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL3942787 | 0.78 | ADAM17 (0.59) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL3942784 | 0.78 | ADAM17 (0.59) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL3938831 | 0.78 | ADAM17 (0.59) | ADAM17MMP13MMP1MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326516-B1 | RHEUMATIC DISEASES; SEPSIS; ANTIULCER AGENTS | AMERICAN CYANAMID COMPANY | 2001-12-04 | — | — | US | claimed |
| US-7488754-B2 | Method for the treatment of polycystic kidney disease | WYETH (US) | 2009-02-10 | — | — | US | disclosed |