Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 16/20 | 0.53 |
| ▸ | MMP13 | P45452 | 10/20 | 0.53 |
| ▸ | MMP1 | P03956 | 8/20 | 0.52 |
| ▸ | MMP9 | P14780 | 8/20 | 0.52 |
| ▸ | MMP14 | P50281 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879785 | 0.98 | ADAM17 (0.52) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL3944455 | 0.89 | ADAM17 (0.57) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL3947785 | 0.89 | ADAM17 (0.57) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL3944450 | 0.89 | ADAM17 (0.57) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL3937331 | 0.87 | ADAM17 (0.57) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL7354194 | 0.81 | SMN1; SMN2 (0.61) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL7377489 | 0.81 | SMN1; SMN2 (0.61) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL7354199 | 0.81 | SMN1; SMN2 (0.61) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL7354188 | 0.81 | SMN1; SMN2 (0.61) | ADAM17MMP13MMP1MMP9MMP14 | |
| SCHEMBL7377492 | 0.81 | SMN1; SMN2 (0.61) | ADAM17MMP13MMP1MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326516-B1 | RHEUMATIC DISEASES; SEPSIS; ANTIULCER AGENTS | AMERICAN CYANAMID COMPANY | 2001-12-04 | — | — | US | disclosed |