Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 3/20 | 0.35 |
| ▸ | NOS1 | P29475 | 3/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4009916 | 0.89 | NOS1 (0.42) | NPC1MAPTRAB9AGFERNOS3 | |
| SCHEMBL3937754 | 0.84 | MAPT (0.49) | DAONPC1MAPTRAB9AGFER | |
| SCHEMBL3947954 | 0.83 | TAAR1 (0.51) | DAONPC1RAB9AIDO1NOS3 | |
| SCHEMBL3947733 | 0.78 | COMT (0.49) | DAONPC1MAPTRAB9AGFER | |
| SCHEMBL3940488 | 0.76 | HRH4 (0.47) | NPC1MAPTRAB9AGFERCYP17A1 | |
| SCHEMBL1922681 | 0.76 | CYP19A1 (0.51) | DAOALDH1A1SMN1; SMN2 | |
| SCHEMBL17967278 | 0.75 | MKNK1 (0.54) | DAONPC1MAPTRAB9AGFER | |
| SCHEMBL4016522 | 0.75 | DYRK1A (0.40) | NPC1MAPTRAB9AGFERALDH1A1 | |
| SCHEMBL17950142 | 0.74 | — | — | |
| SCHEMBL4018767 | 0.73 | NPC1 (0.39) | NPC1MAPTRAB9AGFERALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |