Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.48 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.48 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CCR4 | P51679 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3938487 | 1.00 | CYP1A2 (0.51) | CYP1A2CYP2C19ADRA1DADRA1AADRA1B | |
| SCHEMBL3559410 | 0.84 | KDM4E (0.57) | CD274PDCD1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20294468 | 0.84 | CD274 (0.55) | CD274PDCD1SMN1; SMN2 | |
| SCHEMBL20294470 | 0.84 | CD274 (0.55) | CD274PDCD1SMN1; SMN2 | |
| SCHEMBL2035950 | 0.83 | IDO1 (0.53) | CYP1A2CYP2C19IDO1TDO2CD274 | |
| SCHEMBL188635 | 0.83 | IDO1 (0.53) | CYP1A2CYP2C19IDO1TDO2CD274 | |
| SCHEMBL107960 | 0.83 | ERCC1 (0.60) | CYP2C19SMN1; SMN2CCR4 | |
| SCHEMBL19933192 | 0.83 | SMN1; SMN2 (0.52) | CD274PDCD1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL145365 | 0.83 | ERCC1 (0.60) | CYP2C19SMN1; SMN2CCR4 | |
| SCHEMBL1817651 | 0.82 | GRM5 (0.57) | CYP1A2CYP2C19CD274PDCD1SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017848-A9 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES SUCH AS SYSTEMIC AA AMYLOIDOSIS | PROTEO TECH INC (US) | 2009-04-30 | — | — | WO | claimed |
| WO-2009017848-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES SUCH AS SYSTEMIC AA AMYLOIDOSIS | PROTEO TECH INC. (US) | 2009-02-05 | — | — | WO | claimed |
| WO-2008154083-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF SYNUCLEINOPATHIES | PROTEO TECH INC. (US) | 2008-12-18 | — | — | WO | claimed |
| EP-1511710-B1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF AMYLOID DISEASES AND SYNUCLEINOPATHIES SUCH AS ALZHEIMER S DISEASE, TYPE 2 DIABETES, AND PARKINSON S DISEASE | PROTEOTECH INC (US) | 2013-11-20 | — | — | EP | disclosed |
| WO-2008097692-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASES | PROTEOTECH INC. (US) | 2008-08-14 | — | — | WO | disclosed |