Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | CD274 | Q9NZQ7 | 15/20 | 0.50 |
| ▸ | PDCD1 | Q15116 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20294470 | 0.86 | CD274 (0.55) | SMN1; SMN2TSHRCD274PDCD1KDM4E | |
| SCHEMBL20294468 | 0.86 | CD274 (0.55) | SMN1; SMN2TSHRCD274PDCD1KDM4E | |
| SCHEMBL3938487 | 0.83 | CYP1A2 (0.51) | SMN1; SMN2CD274PDCD1MEN1KMT2A | |
| SCHEMBL3938490 | 0.83 | CYP1A2 (0.51) | SMN1; SMN2CD274PDCD1MEN1KMT2A | |
| SCHEMBL3712217 | 0.79 | ALDH1A1 (0.58) | SMN1; SMN2TSHRCD274PDCD1KDM4E | |
| SCHEMBL3712215 | 0.79 | ALDH1A1 (0.58) | SMN1; SMN2TSHRCD274PDCD1KDM4E | |
| SCHEMBL18710326 | 0.79 | CD274 (0.49) | SMN1; SMN2CD274PDCD1 | |
| SCHEMBL3713849 | 0.77 | NPBWR1 (0.54) | SMN1; SMN2TSHRMAPK1RECQLCD274 | |
| SCHEMBL3713847 | 0.77 | NPBWR1 (0.54) | SMN1; SMN2TSHRMAPK1RECQLCD274 | |
| SCHEMBL3713831 | 0.77 | SMN1; SMN2 (0.63) | SMN1; SMN2CD274PDCD1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018045142-A1 | IMMUNE CHECKPOINT INHIBITORS, COMPOSITIONS AND METHODS THEREOF | POLARIS PHARMACEUTICALS, INC. (US) | 2018-03-08 | — | — | WO | disclosed |