SCHEMBL188635

SCHEMBL188635

O=C(O)[C@@H]1CCCN1Cc1ccc(F)c(F)c1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.53
TDO2 P48775 1/20 0.53
ALDH1A1 P00352 4/20 0.53
TSHR P16473 2/20 0.53
KDM4E B2RXH2 2/20 0.53
CD274 Q9NZQ7 5/20 0.52
PDCD1 Q15116 2/20 0.52
CYP1A2 P05177 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
RAB9A P51151 1/20 0.49
HTT P42858 1/20 0.49
SIGMAR1 Q99720 1/20 0.48
CYP2C19 P33261 1/20 0.47
SCN3A Q9NY46 1/20 0.46
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.46
SPHK1 Q9NYA1 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2035950 1.00 IDO1 (0.53) IDO1TDO2ALDH1A1TSHRKDM4E
SCHEMBL3712217 0.96 ALDH1A1 (0.58) IDO1TDO2ALDH1A1TSHRKDM4E
SCHEMBL3712215 0.96 ALDH1A1 (0.58) IDO1TDO2ALDH1A1TSHRKDM4E
SCHEMBL1819133 0.85 IDO1 (0.53) IDO1TDO2ALDH1A1KDM4ECD274
SCHEMBL2027597 0.85 IDO1 (0.53) IDO1TDO2ALDH1A1KDM4ECD274
SCHEMBL9154842 0.85 IDO1 (0.53) IDO1TDO2ALDH1A1KDM4ECD274
SCHEMBL2032294 0.84 CYP1A2 (0.51) CD274PDCD1CYP1A2CYP2C19SPHK1
SCHEMBL1817183 0.84 CYP1A2 (0.51) CD274PDCD1CYP1A2CYP2C19SPHK1
SCHEMBL3148407 0.84 CYP1A2 (0.51) CD274PDCD1CYP1A2CYP2C19SPHK1
SCHEMBL2029008 0.83 MAOA (0.60) IDO1TDO2ALDH1A1KDM4ECD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747882-A1 DATA STORAGE USING PROTEINS The Hong Kong Polytechnic University (CN) 2026-05-27 EP disclosed
WO-2025015598-A1 DATA STORAGE USING PROTEINS THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2025-01-23 WO disclosed
US-12023316-B2 FAP-activated therapeutic agents, and uses related thereto BACH BIOSCIENCES, LLC (US) 2024-07-02 US disclosed
US-11925655-B2 FAP-activated therapeutic agents, and uses related thereto BACH BIOSCIENCES, LLC (US) 2024-03-12 US disclosed
EP-4299134-A2 FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO Bach Biosciences, LLC (US) 2024-01-03 EP disclosed
US-20230414702-A1 COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER PEPKON SAS (FR) 2023-12-28 US disclosed
US-11759496-B2 Compounds and pharmaceutical use thereof in the treatment of cancer Karoyan, Philippe (FR) 2023-09-19 US disclosed
EP-3154594-B1 FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO BACH BIOSCIENCES LLC (US) 2023-07-19 EP disclosed
US-11302421-B2 Data storage using peptides THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2022-04-12 US disclosed
US-20220087971-A1 FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO BACH BIOSCIENCES, LLC 2022-03-24 US disclosed
WO-2008116053-A2 FAP-ACTIVATED CHEMOTHERAPEUTIC COMPOUNDS, AND METHODS OF USE THEREOF TRUSTEES OF TUFTS COLLEGE (US) 2008-09-25 WO disclosed
EP-1948243-A2 POLYCATION-POLYANION COMPLEXES, COMPOSITIONS AND METHODS OF USE THEREOF Aeris Therapeutics, Inc. (US) 2008-07-30 EP disclosed
US-20080057491-A1 Substrates and inhibitors of antiplasmin cleaving enzyme and methods of use NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2008-03-06 US disclosed
WO-2008022015-A2 RETRO-INVERSO INCRETIN ANALOGUES, AND METHODS OF USE THEREOF TRUSTEES OF TUFTS COLLEGE (US) 2008-02-21 WO disclosed
WO-2007146104-A2 SUBSTRATES AND INHIBITORS OF ANTIPLASMIN CLEAVING ENZYME AND METHODS OF USE MCKEE PATRICK A (US) 2007-12-21 WO disclosed
EP-1863832-A1 AGE INHIBITORS Pharmamens (FR) 2007-12-12 EP disclosed
WO-2007055950-A2 POLYCATION-POLYANION COMPLEXES, COMPOSITIONS AND METHODS OF USE THEREOF AERIS THERAPEUTICS, INC. (US) 2007-05-18 WO disclosed
US-20070110813-A1 Polycation-polyanion complexes, compositions and methods of use thereof AERIS THERAPEUTICS, INC. (US) 2007-05-17 US disclosed
WO-2006103274-A9 AGE INHIBITORS PHARMAMENS (FR) 2007-01-18 WO disclosed
WO-2006103274-A1 AGE INHIBITORS PHARMAMENS (FR) 2006-10-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12023316-B2 FAP-activated therapeutic agents, and uses related thereto FAP, FIBP, GOT1 IDO1 3425/4885TDO2 1770/4885ALDH1A1 749/4885
US-11759496-B2 Compounds and pharmaceutical use thereof in the treatment of cancer VIP, RNASE1, ABCB11 IDO1 771/4885TDO2 4423/4885ALDH1A1 1766/4885
US-20230414702-A1 COMPOUNDS AND PHARMACEUTICAL USE THEREOF IN THE TREATMENT OF CANCER VIP, RNASE1, ABCB11 IDO1 771/4885TDO2 4423/4885ALDH1A1 1766/4885
US-11925655-B2 FAP-activated therapeutic agents, and uses related thereto FAP, FIBP, GOT1 IDO1 3207/4885TDO2 1045/4885ALDH1A1 323/4885
US-20220087971-A1 FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO FAP, FIBP, GOT1 IDO1 3425/4885TDO2 1770/4885ALDH1A1 749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.