Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 6/20 | 0.95 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | F2 | P00734 | 1/20 | 0.61 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342739 | 0.98 | NOTUM (1.00) | NOTUMMAPTF2KCNJ1KMT2A | |
| SCHEMBL3962509 | 0.95 | NOTUM (0.95) | NOTUMMAPTF2KCNJ1KMT2A | |
| SCHEMBL7096356 | 0.95 | NOTUM (0.95) | NOTUMMAPTF2KCNJ1KMT2A | |
| SCHEMBL28994295 | 0.95 | NOTUM (0.95) | NOTUMMAPTF2KCNJ1KMT2A | |
| Hydrochloric Acid SCHEMBL2897369 | 0.95 | NOTUM (0.95) | NOTUMMAPTF2KCNJ1KMT2A | |
| SCHEMBL987888 | 0.90 | NOTUM (0.84) | NOTUMMAPTF2KCNJ1KMT2A | |
| Aniline SCHEMBL28041584 | 0.88 | NOTUM (0.81) | NOTUMMAPTF2KCNJ1KMT2A | |
| SCHEMBL20720498 | 0.86 | NOTUM (0.78) | NOTUMMAPTF2KCNJ1KMT2A | |
| Dimethyl Sulfone SCHEMBL20720495 | 0.86 | NOTUM (0.78) | NOTUMMAPTF2KCNJ1KMT2A | |
| Thiophene SCHEMBL5329358 | 0.86 | NOTUM (0.78) | NOTUMMAPTF2KCNJ1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567467-B | Sarpagine type indole alkaloid derivatives, and preparation method and application thereof | CHONGQING UNIVERSITY (CN) | 2026-05-26 | — | — | CN | disclosed |
| CN-119798228-A | PROTAC compound for targeted degradation of AR/AR-V7 and preparation method and application thereof | 常州大学 | 2025-04-11 | — | — | CN | disclosed |
| CN-119775337-A | Steroid derivative containing pyrazole-thiazolinone heterocycle, and preparation method and application thereof | 汕头大学医学院附属肿瘤医院 | 2025-04-08 | — | — | CN | disclosed |
| CN-119707846-A | Method for preparing cucurbitacin B derivative by strong acid dehydration and peroxy acid oxidation and application | 常州大学 | 2025-03-28 | — | — | CN | disclosed |
| CN-119504911-A | Cucurbitacin B ester derivative and application thereof in medicines for resisting various cancer cells | 常州大学 | 2025-02-25 | — | — | CN | disclosed |
| CN-118546137-A | Preparation method and application of 5, 6-fused bicyclic benzamide derivative | 重庆大学 | 2024-08-27 | — | — | CN | disclosed |
| CN-118530175-A | PDGFR inhibitor and preparation method and application thereof | 中国药科大学 | 2024-08-23 | — | — | CN | disclosed |
| CN-117959266-A | Crocetin-polyethylene glycol monomethyl ether conjugate nanoparticle as well as preparation method and application thereof | 常州大学 | 2024-05-03 | — | — | CN | disclosed |
| CN-117776923-A | Crocetin diester compound and application thereof in liver cancer cell resistance | 常州大学 | 2024-03-29 | — | — | CN | disclosed |
| CN-114853729-B | Quinazoline-2-ketone compound and preparation method and application thereof | 汕头大学医学院 | 2024-03-29 | — | — | CN | disclosed |
| CN-116655510-A | Pyrrolidine compound and preparation method and application thereof | 重庆大学 | 2023-08-29 | — | — | CN | disclosed |
| CN-111454316-B | Steroid chalcone and ester derivative thereof, and preparation method and application thereof | 汕头大学医学院附属肿瘤医院 | 2022-09-20 | — | — | CN | disclosed |
| CN-109020890-B | Preparation and application of saturated aliphatic cyclo-pyrazole derivatives | 南京大学 | 2022-02-08 | — | — | CN | disclosed |
| WO-2020040565-A1 | NANOCOMPOSITE PREPARATION APPARATUS | 영남대학교 산학협력단 | 2020-02-27 | — | — | WO | disclosed |
| CN-107135645-A | For the plant extracts and compound used in wound healing | 凡诺华（英国）有限公司 | 2017-09-05 | — | — | CN | disclosed |
| WO-2017096076-A1 | MICELLES AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-06-08 | — | — | WO | disclosed |
| CN-106794222-A | Methods of diagnosing or treating neurological disorders using P75ECD and/or P75 | 福建天泰医药科技有限公司 | 2017-05-31 | — | — | CN | disclosed |
| WO-2009020270-A1 | DELIVERY SYSTEM FOR NUCLEIC ACIDS USING CATIONIC POLYMER CONJUGATES | POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) | 2009-02-12 | — | — | WO | disclosed |
| CN-1056832-C | Carbocyclic and heterocyclic annelleted dihydropyridine and application of same in preparation of pharmaceutical | BOEHRINGER INGELHEIM KG (DE) | 2000-09-27 | — | — | CN | disclosed |
| EP-0267005-A2 | Compositions for preventing secondary cataracts | BAYLOR COLLEGE OF MEDICINE (US) | 1988-05-11 | — | — | EP | disclosed |