Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 11/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PLTP | P55058 | 3/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939937 | 1.00 | RORC (0.52) | RORCAOC3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL5547033 | 0.91 | AOC3 (0.50) | RORCAOC3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3930927 | 0.89 | RORC (0.54) | RORCAOC3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL5547036 | 0.87 | RORC (0.52) | RORCAOC3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL5547039 | 0.87 | RORC (0.52) | RORCAOC3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4990301 | 0.85 | PIK3CD (0.60) | RORCAOC3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL4990287 | 0.85 | PIK3CD (0.60) | RORCAOC3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3933160 | 0.85 | RORC (0.56) | RORCAOC3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3936254 | 0.83 | AOC3 (0.56) | RORCAOC3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3931236 | 0.83 | AOC3 (0.55) | RORCAOC3PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786792-B1 | THIAZOLE DERIVATIVES HAVING VAP-1 INHIBITORY ACTIVITY | ASTELLAS PHARMA INC (JP) | 2009-04-08 | — | — | EP | disclosed |
| EP-1786792-A2 | THIAZOLE DERIVATIVES HAVING VAP-1 INHIBITORY ACTIVITY | Astellas Pharma Inc. (JP) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006011631-A2 | THIAZOLE DERIVATIVES HAVING VAP-1 INHIBITORY ACTIVITY | ASTELLAS PHARMA INC. (JP) | 2006-02-02 | — | — | WO | disclosed |