Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KCNA5 | P22460 | 7/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3754213 | 0.90 | KCNA5 (0.65) | P2RX7TDP1KCNA5KCNH2TP53 | |
| SCHEMBL3942624 | 0.87 | KCNA5 (0.67) | TDP1KCNA5KCNH2KMT2A | |
| SCHEMBL4154462 | 0.86 | P2RX7 (0.61) | P2RX7TDP1KCNA5KCNH2KMT2A | |
| SCHEMBL3753805 | 0.85 | KCNA5 (0.74) | P2RX7TDP1KCNA5KCNH2TP53 | |
| SCHEMBL3754120 | 0.83 | P2RX7 (0.59) | P2RX7TDP1KCNA5KCNH2TP53 | |
| SCHEMBL3756454 | 0.81 | P2RX7 (0.57) | P2RX7TDP1KCNA5KCNH2TP53 | |
| SCHEMBL3946126 | 0.81 | KMT2A (0.64) | TDP1KCNA5KCNH2TP53KMT2A | |
| SCHEMBL3752188 | 0.80 | KCNA5 (0.59) | P2RX7KCNA5TP53KMT2AHPGD | |
| SCHEMBL3758883 | 0.79 | KCNA5 (0.71) | P2RX7KCNA5KCNH2TP53HPGD | |
| SCHEMBL3751983 | 0.78 | KCNA5 (0.58) | P2RX7KCNA5KCNH2TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | claimed |
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |