Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3750088 | 0.91 | P2RX7 (0.62) | P2RX7TDP1KCNA5SCN9ASCN5A | |
| SCHEMBL3940692 | 0.86 | P2RX7 (0.57) | P2RX7TDP1KCNA5KCNH2KMT2A | |
| SCHEMBL3942624 | 0.85 | KCNA5 (0.67) | TDP1KCNA5SCN9ASCN5AKCNH2 | |
| SCHEMBL3756940 | 0.84 | KCNA5 (0.70) | P2RX7TDP1KCNA5SCN9ASCN5A | |
| SCHEMBL3751973 | 0.84 | P2RX7 (0.63) | P2RX7KCNA5SCN9ASCN5AKCNH2 | |
| SCHEMBL3746039 | 0.82 | P2RX7 (0.61) | P2RX7KCNA5SCN9ASCN5AKCNH2 | |
| SCHEMBL3750633 | 0.82 | P2RX7 (0.66) | P2RX7TDP1KCNA5SCN9ASCN5A | |
| SCHEMBL3746181 | 0.81 | P2RX7 (0.58) | P2RX7KCNA5SCN9ASCN5AKCNH2 | |
| SCHEMBL3750747 | 0.80 | P2RX7 (0.58) | P2RX7KCNA5SCN9ASCN5AKCNH2 | |
| SCHEMBL3756360 | 0.80 | KCNA5 (0.68) | P2RX7KCNA5SCN9ASCN5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | claimed |
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |