Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014518 | 0.81 | SLC6A4 (0.47) | HRH3SLC6A4SLC6A2SLC6A3SOS1 | |
| SCHEMBL4019960 | 0.80 | SLC6A4 (0.68) | HRH3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3942750 | 0.77 | SLC6A4 (0.68) | HRH3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3941657 | 0.76 | HRH3 (0.48) | HRH3SLC6A4SLC6A2SLC6A3SOS1 | |
| SCHEMBL4164299 | 0.75 | SLC6A4 (0.46) | HRH3SLC6A4SLC6A2SLC6A3SOS1 | |
| SCHEMBL7460955 | 0.71 | SLC6A2 (0.44) | HRH3SLC6A4SLC6A2SLC6A3HIF1A | |
| SCHEMBL7463737 | 0.71 | SLC6A2 (0.43) | HRH3SLC6A4SLC6A2SLC6A3HIF1A | |
| SCHEMBL11473295 | 0.69 | ADRB1 (0.69) | SLC6A4LMNAHTTMAPTSMN1; SMN2 | |
| SCHEMBL5544824 | 0.65 | HTR2A (0.54) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11468731 | 0.64 | ADRB1 (0.56) | SLC6A4ALDH1A1MAPTADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137562-A1 | SUBSTITUTED BENZYL AMINE COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2009-05-28 | — | — | US | disclosed |
| US-7479493-B2 | Substituted benzyl amine compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-20 | — | — | US | disclosed |
| US-20080045509-A1 | SUBSTITUTED BENZYL AMINE COMPOUNDS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045509-A1 | SUBSTITUTED BENZYL AMINE COMPOUNDS | HRH3, HNMT, HRH4 | HRH3 1/4885SLC6A4 8/4885SLC6A2 17/4885 |
| US-20090137562-A1 | SUBSTITUTED BENZYL AMINE COMPOUNDS | HRH3, HNMT, HRH4 | HRH3 1/4885SLC6A4 8/4885SLC6A2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.