Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | TP53 | P04637 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.53 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.53 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.53 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.53 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756806 | 0.89 | ALDH1A1 (0.66) | KMT2ATP53ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3942840 | 0.88 | ALDH1A1 (0.69) | KMT2ATP53ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16797450 | 0.85 | TP53 (0.76) | KMT2ATP53ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3762790 | 0.84 | KMT2A (0.60) | KMT2ATP53ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3753733 | 0.84 | ALDH1A1 (0.62) | KMT2ATP53ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3755999 | 0.82 | ALDH1A1 (0.86) | KMT2ATP53ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3758084 | 0.81 | ALDH1A1 (0.67) | KMT2ATP53ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3753631 | 0.81 | KMT2A (0.69) | KMT2ATP53ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3750606 | 0.81 | ALDH1A1 (0.60) | KMT2ATP53ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3749120 | 0.81 | SCN9A (0.55) | KMT2AALDH1A1LMNASMN1; SMN2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | claimed |
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |