Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 9/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753733 | 0.93 | ALDH1A1 (0.62) | ALDH1A1LMNASMN1; SMN2KMT2ATP53 | |
| SCHEMBL3758084 | 0.93 | ALDH1A1 (0.67) | ALDH1A1LMNASMN1; SMN2KMT2ATP53 | |
| SCHEMBL3758129 | 0.90 | ALDH1A1 (0.76) | ALDH1A1LMNASMN1; SMN2KMT2ATP53 | |
| SCHEMBL3751057 | 0.90 | SCN9A (0.66) | ALDH1A1SCN9ASCN5AKCNH2TDP1 | |
| SCHEMBL3941925 | 0.88 | KMT2A (0.80) | ALDH1A1LMNASMN1; SMN2KMT2ATP53 | |
| SCHEMBL3945362 | 0.86 | ALDH1A1 (0.54) | ALDH1A1LMNASMN1; SMN2KMT2ATP53 | |
| SCHEMBL3756806 | 0.86 | ALDH1A1 (0.66) | ALDH1A1LMNASMN1; SMN2KMT2ATP53 | |
| SCHEMBL3946126 | 0.86 | KMT2A (0.64) | ALDH1A1LMNASMN1; SMN2KMT2ATP53 | |
| SCHEMBL3749120 | 0.85 | SCN9A (0.55) | ALDH1A1LMNASMN1; SMN2KMT2ASCN9A | |
| SCHEMBL3759970 | 0.84 | SCN9A (0.65) | SCN9ASCN5AKCNH2KCNQ2KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |