Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4924142 | 0.74 | POLB (0.38) | ALDH1A1LMNAMAPTHSP90AA1POLB | |
| SCHEMBL4924126 | 0.74 | POLB (0.38) | ALDH1A1LMNAMAPTHSP90AA1POLB | |
| SCHEMBL16824835 | 0.73 | MAPT (0.52) | ALDH1A1LMNAMAPTPOLBSMN1; SMN2 | |
| SCHEMBL16824939 | 0.73 | MAPT (0.52) | ALDH1A1LMNAMAPTPOLBSMN1; SMN2 | |
| SCHEMBL143673 | 0.71 | KMT2A (0.39) | ALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL3981081 | 0.71 | KMT2A (0.39) | ALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL58248 | 0.70 | ALDH1A1 (0.43) | ALDH1A1HSP90AA1POLBMMP2KMT2A | |
| SCHEMBL12433575 | 0.70 | ALDH1A1 (0.43) | ALDH1A1HSP90AA1POLBMMP2KMT2A | |
| SCHEMBL59929 | 0.70 | ALDH1A1 (0.43) | ALDH1A1HSP90AA1POLBMMP2KMT2A | |
| SCHEMBL4617596 | 0.69 | ALDH1A1 (0.48) | ALDH1A1HSP90AA1POLBMMP2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101595-B2 | Antiviral indoles | Istituto di Ricerche di Biologia Molecolare P. Angletti SpA (IT) | 2012-01-24 | — | — | US | disclosed |
| US-7989438-B2 | Therapeutic compounds | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-08-02 | — | — | US | disclosed |