Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16824835 | 1.00 | MAPT (0.52) | MAPTALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL16824857 | 0.83 | ALDH1A1 (0.40) | MAPTALDH1A1LMNASMN1; SMN2MEN1 | |
| SCHEMBL16569815 | 0.79 | SIRT6 (0.54) | MAPTALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL5724734 | 0.75 | MAPT (0.68) | MAPTALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL18186271 | 0.73 | MAPT (0.65) | MAPTALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL394197 | 0.73 | ALDH1A1 (0.39) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL5235107 | 0.70 | MAPT (0.45) | MAPTALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL29310298 | 0.69 | SIRT6 (0.51) | MAPTALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL5235116 | 0.69 | MAPT (0.42) | MAPTALDH1A1LMNASMN1; SMN2TP53 | |
| SCHEMBL2105411 | 0.68 | MAPT (0.75) | MAPTALDH1A1LMNASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083625-A1 | PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS | Almac Discovery Limited (GB) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015092431-A1 | PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2015-06-25 | — | — | WO | disclosed |