Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 4/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946983 | 0.94 | CASR (0.43) | CASRPDK1CNR1KDM4EMEN1 | |
| SCHEMBL3945390 | 0.92 | CASR (0.42) | CASRCNR1KDM4EMEN1KMT2A | |
| SCHEMBL4036518 | 0.92 | CASR (0.40) | CASRPDK1CNR1KDM4EMEN1 | |
| SCHEMBL3952113 | 0.91 | CASR (0.44) | CASRCNR1ACACB | |
| SCHEMBL3947316 | 0.91 | CASR (0.41) | CASRPDK1CNR1MEN1KMT2A | |
| SCHEMBL3945754 | 0.90 | CASR (0.41) | CASRCNR1KDM4EMEN1KMT2A | |
| SCHEMBL3942446 | 0.87 | CASR (0.41) | CASRPDK1CNR1RPS6KB1ACACB | |
| SCHEMBL3951654 | 0.86 | CASR (0.41) | CASRCNR1MEN1KMT2A | |
| SCHEMBL3951537 | 0.85 | CASR (0.46) | CASRMEN1KMT2ACSF1R | |
| SCHEMBL3945231 | 0.85 | HPGD (0.40) | CASRKDM4EMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |