Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | EDNRA | P25101 | 3/20 | 0.39 |
| ▸ | CASR | P41180 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGFR | P43088 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946983 | 0.87 | CASR (0.43) | CASRALDH1A1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL3942465 | 0.85 | CASR (0.41) | CASRKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL3947316 | 0.85 | CASR (0.41) | CASRLMNAMEN1KMT2A | |
| SCHEMBL3942446 | 0.85 | CASR (0.41) | CASRLMNA | |
| SCHEMBL3945390 | 0.84 | CASR (0.42) | CASRALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL4036518 | 0.84 | CASR (0.40) | CASRALDH1A1KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL3951654 | 0.84 | CASR (0.41) | CASRMAPTMEN1KMT2A | |
| SCHEMBL3952113 | 0.84 | CASR (0.44) | CASRALDH1A1 | |
| SCHEMBL3951537 | 0.83 | CASR (0.46) | HPGDCASRALDH1A1MEN1KMT2A | |
| SCHEMBL3945754 | 0.82 | CASR (0.41) | HPGDCASRALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718632-B1 | PYRIMIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SANOFI AVENTIS (FR) | 2009-04-22 | — | — | EP | claimed |